In gentle of those observations, sirtuins are recognised as novel regulators of immuno-metabolism in human beings. Aside from SIRT1, SIRT2 has long been not long ago linked to cytoskeleton reworking and activation of NLRP3 in intracellular pathways[117]. Apart from the activation of innate immunity, the contribution of adaptive immune cells https://www.directivepublications.org/journal-of-diabetology-research/