Gastrointestinal (GI): NSAIDs that block COX-1 exercise have correlations with GI issues due to the inhibition on the synthesis of gastroprotective brokers like PGE2 together with other prostaglandins. This inhibition results in diminished mucin manufacturing by gastric epithelial cells, fewer bicarbonate secretion, and less epithelial cell turnover, amongst other steps. https://ramseyh135qsu0.blogdun.com/profile