New selective PAD4 inhibitors binding a calcium-deficient kind of the PAD4 enzyme have validated the essential enzymatic position of human and mouse PAD4 in equally histone citrullination and neutrophil extracellular trap development for, to our know-how, The very first time. The therapeutic opportunity of PAD4 inhibitors can now be explored. https://joyceg443scn6.wikiusnews.com/user